Dataset Information


Illumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas from the HERBY clinical trial

ABSTRACT: We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas within the HERBY clinical trial. The HERBY trial was a phase-II open-label, randomised, multicentre trial evaluating bevacizumab in patients with newly-diagnosed non-brainstem HGG between the ages of 3-18yrs. The 450K methylation array was used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of origin the time and place in which tumours arise. Methylation arrays provide data for an integrated molecular diagnosis of brain tumours and define specific molecular subgroups and subtypes of high grade gliomas carrying distinct driver mutations and patterns of somatic alterations.

ORGANISM(S): Homo sapiens

SUBMITTER: Alan Mackay 

PROVIDER: E-MTAB-5552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2017-09-28 | E-MTAB-5528 | biostudies-arrayexpress
2019-06-01 | E-MTAB-7800 | biostudies-arrayexpress
2019-12-10 | E-MTAB-7575 | biostudies-arrayexpress
2019-04-04 | E-MTAB-6955 | biostudies-arrayexpress
2016-03-11 | E-MTAB-3903 | biostudies-arrayexpress
2012-12-31 | E-GEOD-40105 | biostudies-arrayexpress
2017-12-15 | E-MTAB-4969 | biostudies-arrayexpress
2016-05-15 | E-GEOD-76171 | biostudies-arrayexpress
2016-01-15 | E-GEOD-65027 | biostudies-arrayexpress
2015-03-31 | E-GEOD-66210 | biostudies-arrayexpress