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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of peripheral blood mononuclear cells (PBMCs) 8 hours after exposure to 1 Gy of carbon or iron ions

ABSTRACT: Under certain circumstances, humans can be exposed to ionizing radiation from heavy ions. Examples are cancer patients undergoing particle therapy (e.g. carbon ions) or astronauts in deep Space missions (iron ions which contribute for a large fraction to the possible health effects of cosmic radiation because of their high ionisation power). Understanding the differences in the cellular response to low- and high-LET radiation is important in order to adequately model risk estimates based on extrapolations from low-LET exposures. To address this need, we compared the transcriptional profiles of freshly isolated peripheral blood mononuclear cells after exposure to 1 Gy of X-rays, iron ions or carbon ions. Data of X-ray exposure have been submitted in E-MTAB-3463: https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-3463/.

ORGANISM(S): Homo sapiens

SUBMITTER: Roel Quintens

PROVIDER: E-MTAB-5761 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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