Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

ABSTRACT: We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue on controls (daGS;InRDN>GFP- RNAi) and reduced insulin signalling background upon control RNAi (daGS;InRDN>GFPRNAi +RU486) and upon FKH RNAi (daGS;InRDN>FKH- RNAi +RU486). InR-DN stock used: K1409A.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ekin Bolukbasi 

PROVIDER: E-MTAB-6056 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress