Transcription profiling of Drosophila to investigate mutations affecting aggressive behavior

ABSTRACT: Epistasis and pleiotropy are important features of the genetic architecture of quantitative traits, but are difficult to assess in outbred populations. We performed a diallel cross among Drosophila P-element mutations previously associated with hyper-aggressive behavior, and demonstrated extensive epistatic and pleiotropic effects on aggression, brain morphology, and genome wide gene expression. Epistatic interactions were often of greater magnitude than homozygous effects, and the topology of the epistatic networks varied among the traits. The transcriptional signature of the homozygous and double heterozygous genotypes derived from the six mutations implies a large mutational target size for aggressive behavior and evolutionarily conserved genetic mechanisms and neural signaling pathways

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Liesbeth Zwarts 

PROVIDER: E-MTAB-653 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress