Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

ABSTRACT: The development of reduced-risk products is aimed at providing adult smokers, who are unable to quit, with alternatives to cigarettes that present less risk of harm and smoking-related disease. The use of flavors in the development of these reduced-risk products fulfils an important role in product acceptance. While most flavors are also used by the food industry and are considered safe when ingested, their impact when inhaled is still debated. To overcome this research gap, we developed a three-step approach combining real-time cellular analysis, phenotypic high-content screening assays and gene expression analysis. As a case study, a list of 28 flavors, commonly used in e-liquid formulation, were selected and dissolved individually or as a mixture in a Base Solution composed of propylen

ORGANISM(S): Homo sapiens

SUBMITTER: Carole Mathis 

PROVIDER: E-MTAB-7748 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress