Open TG-GATEs (in vivo repeat dosing)

ABSTRACT: The Toxicogenomics Project was a 5-year collaborative project (2002-2007) by a consortium comprising the Japanese government and several pharmaceutical companies. The project produced the 'Toxicogenomics Project-Genomics Assisted Toxicity Evaluation system' (TG-GATEs), a large-scale database of transcriptomics and pathology data potentially useful for predicting the toxicity of new chemical entities. Conventional in vivo toxicology data was collected from single dose and repeat dosing studies on rats, and gene expression measured for the liver (and kidney in some cases). To provide information on species differences, gene expression was also measured in rat and human hepatocytes treated with the chemicals in vitro. Approximately 130 chemicals, primarily medicinal compounds, were tested at

INSTRUMENT(S): Agilent High resolution C scanner

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ruth Akhtar 

PROVIDER: E-MTAB-800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress