Transcription profiling of rat liver and kidney (F344 strain) following exposure to benzene, trichloroethylene, methyl mercury and their mixtures

ABSTRACT: The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest-Observed-Adverse-Effect-Level (LOAEL) or at a two- or three-fold lower concentration individually or in binary or ternary mixtures. The compounds had strong antagonistic effects on each others gene expression changes, which included several genes encoding Phase I and II metabolizing enzymes. On the other hand, the mixtures affected the expression of “novel” genes that were not or little affected by the individual compounds. Based on gene expression change

ORGANISM(S): Rattus norvegicus

SUBMITTER: Peter Hendriksen 

PROVIDER: E-TOXM-30 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress