Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

RNA-seq of diaphyseal bone from sclerostin-neutralizing antibody treated mice

ABSTRACT: Ten-week-old male C57/bl6 mice were treated with a sclerostin-inhibiting antibody or vehicle for 2 weeks. Tibial diaphyses were removed, bone marrow flushed and total RNA was isolated for RNA-sequencing.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Ugur Ayturk

PROVIDER: E-MTAB-8113 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome.

Kedlaya Rajendra R Veera Shreya S Horan Daniel J DJ Moss Rachel E RE Ayturk Ugur M UM Jacobsen Christina M CM Bowen Margot E ME Paszty Chris C Warman Matthew L ML Robling Alexander G AG

Science translational medicine 20131101 211

Osteoporosis pseudoglioma syndrome (OPPG) is a rare genetic disease that produces debilitating effects in the skeleton. OPPG is caused by mutations in LRP5, a WNT co-receptor that mediates osteoblast activity. WNT signaling through LRP5, and also through the closely related receptor LRP6, is inhibited by the protein sclerostin (SOST). It is unclear whether OPPG patients might benefit from the anabolic action of sclerostin neutralization therapy (an approach currently being pursued in clinical tr ...[more]

PMID: 24225945

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