Whole-genome mRNA expression analyses of pro- and anti-inflammatory features of LPS-matured moDCs and suggests a role for β-catenin inhibition in production of more potent therapeutic moDCs

ABSTRACT: The transcription factor β-catenin has been shown to be active in different types of dendritic cells (DCs) with ability to induce tolerogenic or anti-inflammatory features. Monocyte-derived dendritic cells (moDCs) have been widely used in dendritic cell-based cancer therapy, but so far with limited clinical efficacy. It is possible that aberrant differentiation or induction of dual pro- and anti-inflammatory features may decrease the moDCs efficiency to stage the immune attack on cancer cells. Here we show, using moDCs derived from healthy buffycoats, that β-catenin is detectable in both immature and lipopolysaccharide (LPS)-matured DCs.

INSTRUMENT(S): Agilent Scanner G2505

ORGANISM(S): Homo sapiens

SUBMITTER: Anne Margrete Oyan 

PROVIDER: E-MTAB-8330 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress