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Comparison of the effects of curcumin on rat neonate lungs in control animals and rats affected by Intra-Uterine Growth restriction following Low Protein Diet of the mothers (LPD Model) at postnatal day 11

ABSTRACT: Neonates born pre-term or/and at low weight often suffer from defective lung function where PPAR-gamma cascades play an important role. Curcumin is a PPAR gamma agonist at postnatal day 11

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daniel Vaiman

PROVIDER: E-MTAB-8722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparison of the effects of curcumin on rat neonate lungs in control animals and rats affected by Intra-Uterine Growth restriction following Low Protein Diet of the mothers (LPD Model)

Project description:Neonates born pre-term or/and at low weight often suffer from defective lung function where PPAR-gamma cascades play an important role. Curcumin is a PPAR gamma agonist

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Forskolin induction of fusion in BeWo trophoblast cells

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Project description:STOX1 overexpressing placentas generate preeclampsia-like symptoms in pregnant mice. These symptoms are reverted by aspirin. The experiment aims at analyzing placental expression in Transgenic/non transgenic with and withou aspirin, in the placentas at 16,5 days post-coïtum. There are two strains of transgenic mice that express the transgene at different levels: STOX42 about 15 fold that of STOX13. STOX13 expressed the human STOX1 roughly at the level of the mouse endogeneous Stox1 in the placenta.

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Project description:Three variants of STOX1 (Y153H, T188N, and R364X) were associated to diseases of pregnancy (preeclampsia and HELLP syndrome). Here we analyze the expression profile of these mutations (6 independent clones) starting from two independent Knocked-Out cell lines (KO5 and KO21).

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Project description:Long-term consequences of preeclampsia were studied by high-throughput approaches (Transcriptomics, Luminex cytokine profile) in mice 8 months after the disease in the heart, in the endothelial cells and in the plasma. In the heart we found a persisting ventricular hypertrophy with an altered histology and an abnormal ultrasound Doppler profile under effort simulation by dobutamine injection. The transcriptomic profile of the endothelium revealed a deregulation for 1149 genes (327 down-regulated and 822 up-regulated, with a threshold of 1.5, p<0.05). The up-regulated genes could be grouped consistently in gene pathways and gene ontology terms mainly focused on Inflammation and Stress sensu lato. A cytokine profile of the mouse serum was carried out. Using a combination of 8 cytokines (Cxcl13, Cxcl16, Cxcl11, Il-16, Il-10, Il-2, Il-4 and Ccl1) in a Discriminant Analysis, we were able to separate unambiguously the mice having had a preeclamptic pregnancy from the controls. Seven out of eight of these cytokines (with the exception of Il-16) varied in the same direction in the endothelium and in the plasma. In sum, our study shows that preeclampsia alone is able to trigger considerable long-term consequences, and suggests that specific cytokines could help to improve the follow-up of patients long after a preeclamptic pregnancy.

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