Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis

ABSTRACT: The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. Here we sequenced the small intestinal epithelium from mice infected with Nippostrongylus brasiliensis to determine how the intestinal epithelium adapts in the context of an infection. By comparing these data to small intestinal organoids treated with cytokines (see related accessions) we determine that the intestinal epithelial response to N. brasiliensis infection correspond to a type II infection driven by IL-13.

ORGANISM(S): Mus musculus

SUBMITTER: Claire Drurey 

PROVIDER: E-MTAB-9183 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.

Lindholm Håvard T HT   Parmar Naveen N   Drurey Claire C   Campillo Poveda Marta M   Vornewald Pia M PM   Ostrop Jenny J   Díez-Sanchez Alberto A   Maizels Rick M RM   Oudhoff Menno J MJ  

Science immunology 20220513 71

The intestinal tract is a common site for various types of infections including viruses, bacteria, and helminths, each requiring specific modes of immune defense. The intestinal epithelium has a pivotal role in both immune initiation and effector stages, which are coordinated by lymphocyte cytokines such as IFNγ, IL-13, and IL-22. Here, we studied intestinal epithelial immune responses using organoid image analysis based on a convolutional neural network, transcriptomic analysis, and in vivo inf  ...[more]

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