Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Reanalysis of Pandey lab's draft of the human proteome

ABSTRACT: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides was lacking. To this end, Akhilesh Pandey's lab reported a draft map of the human proteome based on high resolution Fourier transform mass spectrometry-based proteomics technology, which included an in-depth proteomic profiling of 30 histologically normal human samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells ( http://dx.doi.org/10.1038/nature13302 ). The profiling resulted in identification of proteins encoded by greater than 17,000 genes accounting for ~84% of the total annotated protein-coding genes in humans. This large human proteome catalog (available as an interactive web-based resource at http://www.humanproteomemap.org) complements available human genome and transcriptome data to accelerate biomedical research in health and disease. Pandey's lab and collaborators request that those considering use of this primary dataset for commercial purposes contact pandey@jhmi.edu. The full details of this study can be found in the PRIDE database: www.ebi.ac.uk/pride/archive/projects/PXD000561/. This ArrayExpress entry represents a top level summary of the metadata only which formed the basis of the reanalysis performed by Joyti Choudhary's team ( jc4@sanger.ac.uk ), results of which are presented in the Expression Atlas at EMBL-EBI : http://www.ebi.ac.uk/gxa/experiments/E-PROT-1.

ORGANISM(S): Homo sapiens

SUBMITTER: Joyti Choudhary

PROVIDER: E-PROT-1 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Functional annotation of proteome encoded by human chromosome 22.

Pinto Sneha M SM Manda Srikanth S SS Kim Min-Sik MS Taylor KyOnese K Selvan Lakshmi Dhevi Nagarajha LD Balakrishnan Lavanya L Subbannayya Tejaswini T Yan Fangfei F Prasad T S Keshava TS Gowda Harsha H Lee Charles C Hancock William S WS Pandey Akhilesh A

Journal of proteome research 20140429 6

As part of the chromosome-centric human proteome project (C-HPP) initiative, we report our progress on the annotation of chromosome 22. Chromosome 22, spanning 51 million base pairs, was the first chromosome to be sequenced. Gene dosage alterations on this chromosome have been shown to be associated with a number of congenital anomalies. In addition, several rare but aggressive tumors have been associated with this chromosome. A number of important gene families including immunoglobulin lambda l ...[more]

PMID: 24669763

Publication: 1/2

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Dataset Information

Reanalysis of Pandey lab's draft of the human proteome

Publications

Functional annotation of proteome encoded by human chromosome 22.

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