Transcription profiling of human primary fibroblasts from 10 anatomic sites expanded in DMEM supplemented with 10% fetal calf serum, penicillin/streptomycin, and glutamine (Tumor as Wound)

ABSTRACT: Cancer invasion and metastasis have been likened to wound healing gone awry. Despite striking parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes, and their prognostic implications, are unclear. Here, based on gene expression profiles of fibroblasts from 10 anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by th

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-2287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress