Translation profiling of human lung fibroblasts treated or not with rapamycin to better understand the molecular mechanism behind alternative translational routes

ABSTRACT: Deregulation of translational control is frequently implicated in the establishment and maintenance of the cancer phenotype. Anti-cancer drugs targeting protein synthesis are confronted by the problem that genes can exploit alternative translational mechanisms. To better understand the molecular mechanism behind these alternative translational routes we have exploited an ex-vivo assay that follows a competitive re-recruitment of cellular mRNAs onto polysomes in cells treated or not with rapamycin.

ORGANISM(S): Homo sapiens

SUBMITTER: Joseph Curran 

PROVIDER: E-TABM-205 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress