Unknown,Transcriptomics,Genomics

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Transcription profiling of liver from wild type and tumor suppressor Apc knock-out mice

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). This work aims to demonstrate a key role for the Wnt/beta-catenin pathway in liver embryonic growth and in controlling the fate of hepatoblasts, preventing them to differentiate towards the hepatocyte lineage, and guiding them to a duct morphogenesis. Through the inactivation of Apc (adenomatous Polyposis Coli) tumor suppressor gene in hepatoblasts by a Cre-loxP strategy, the ectopic activation of beta-catenin targeted in hepatoblasts after liver bud formation leads to a lethal embryonic phenotype, characterized by liver hypoplasia, a blockade of hepatocyte differentiation and commitment to a biliary fate. (this work was supported by INSERM and the B^SLigue Nationale

ORGANISM(S): Mus musculus

SUBMITTER: Fabien Petel Programme "Cartes d'IdentitM-CM-) des Tumeurs" (CIT) 

PROVIDER: E-TABM-295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

Decaens Thomas T   Godard Cécile C   de Reyniès Aurélien A   Rickman David S DS   Tronche François F   Couty Jean-Pierre JP   Perret Christine C   Colnot Sabine S  

Hepatology (Baltimore, Md.) 20080101 1

<h4>Unlabelled</h4>During hepatogenesis, after the liver has budded out of the endoderm, the hepatoblasts quickly expand and differentiate into either hepatocytes or biliary cells, the latter of which arise only within the ductal plate surrounding the portal vein. Because the Wnt/beta-catenin pathway is involved in liver homeostasis and regeneration and in liver carcinogenesis, we investigated here a role for Wnt/beta-catenin signaling in the embryonic liver. A cyclization recombination (Cre)/lo  ...[more]

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