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Transcription profiling of pancreata from wild type, KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice

ABSTRACT: Transcription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice

ORGANISM(S): Mus musculus

SUBMITTER: Henrik Einwaechter

PROVIDER: E-TABM-304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

Siveke Jens T JT Einwächter Henrik H Sipos Bence B Lubeseder-Martellato Clara C Klöppel Günter G Schmid Roland M RM

Cancer cell 20070901 3

Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras(G12D) by crossing Elastase-Tgfa mice with p48(+/Cre);Kras(+/LSL-G12D) mice. We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN). Microar ...[more]

PMID: 17785207

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