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Comparative genomic hybridization of Saccharomyces cerevisiae - analysis of gross chromosomal rearrangements

ABSTRACT: Determine changes in genomic copy across the entire genome for isolated strains with selected gross chromosomal rearrangements relative to the wild-type strain.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Chris Putnam

PROVIDER: E-TABM-714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Specific pathways prevent duplication-mediated genome rearrangements.

Putnam Christopher D CD Hayes Tikvah K TK Kolodner Richard D RD

Nature 20090729 7258

We have investigated the ability of different regions of the left arm of Saccharomyces cerevisiae chromosome V to participate in the formation of gross chromosomal rearrangements (GCRs). We found that the 4.2-kilobase HXT13-DSF1 region sharing divergent homology with chromosomes IV, X and XIV, similar to mammalian segmental duplications, was 'at risk' for participating in duplication-mediated GCRs generated by homologous recombination. Numerous genes and pathways, including SGS1, TOP3, RMI1, SRS ...[more]

PMID: 19641493

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