Autoantibodies against type I interferons in COVID-19 infection: A systematic review and meta-analysis.

ABSTRACT:

Objectives

In this study, we aimed to study the rate of autoantibodies against type I interferons (IFNs) in patients with COVID-19 and analyze its dependence on severity of infection and some other variables.

Methods

A systemic review with the search terms: "COVID-19" or "SARS-CoV-2" and "autoantibodies" or "autoantibody" and "IFN" or "interferon" for the period 20 December 2019 to 15 August 2022 was carried out using PubMed, Embase, Cochrane, and Web of Science. R 4.2.1 software was used for meta-analysis of the published results. Pooled risk ratios and 95% confidence intervals (CIs) were calculated.

Results

We identified eight studies involving 7729 patients, of whom 5097 (66%) had severe COVID-19 and 2632 (34%) had mild or moderate symptoms. The positive rate of an

SUBMITTER: Wang X 

PROVIDER: S-EPMC10005838 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature