Effects of diarylbutane lignans from Schisandra chinensis fruit on SARS-CoV-2 3CL^pro and PL^pro and their in vitro anti-inflammatory properties.

ABSTRACT:

Background

Schisandra chinensis fruit is a well-known traditional Chinese medicine (TCM), whose extract has a potent inhibitory effect on the severe acute respiratory syndrome-coronavirus-2 (SARS‑CoV‑2) 3-chymotrypsin-like protease (3CL^pro) and papain-like protease (PL^pro).

Purpose

This work aims to find the active components from the fruit of S. chinensis against SARS‑CoV‑2 3CL^pro and PL^pro.

Materials and methods

The chemical constituents of the fruit of S. chinensis were retrieved based on the electronic databases, such as Web of Science, PubMed, Medline Plus, and CNKI. Molecular docking was used to screen the active components against SARS‑CoV‑2 3CL^pro and PL^pro. Potential hit co

SUBMITTER: Li B 

PROVIDER: S-EPMC10005971 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature