Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis.
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ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC10006202 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis.
Yang Wei W Zhang Chen C Wu Yan-Hua YH Liu Li-Bo LB Zhen Zi-Da ZD Fan Dong-Ying DY Song Zheng-Ran ZR Chang Jia-Tong JT Wang Pei-Gang PG An Jing J
Virologica Sinica 20221012 1
Zika virus (ZIKV) poses a serious threat to global public health due to its close relationship with neurological and male reproductive damage. However, deficiency of human testicular samples hinders the in-depth research on ZIKV-induced male reproductive system injury. Organoids are relatively simple in vitro models, which could mimic the pathological changes of corresponding organs. In this study, we constructed a 3D testicular organoid model using primary testicular cells from adult BALB/c mic ...[more]
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