Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.

ABSTRACT:

Background

Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour mutational burden reportedly tend to respond to ICIs. However, there are several conflicting data. Therefore, we focused on the original function of neoantigenic mutations and their impact on the tumour microenvironment (TME).

Methods

We evaluated 88 high-frequency microsatellite instability (MSI-H) colorectal cancers and analysed the function of the identified neoantigenic mutations and their influence on programmed cell death 1 (PD-1) blockade efficacy. The results were validated using The Cancer Genome Atlas (TCGA) datasets.

Results

We identified frames

SUBMITTER: Ishino T 

PROVIDER: S-EPMC10006227 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature