Genetic association of the rs17782313 polymorphism with antipsychotic-induced weight gain.

ABSTRACT:

Rationale

Weight gain is a frequent side effect of treatment with SGAs (second-generation antipsychotics) and a leading cause for nonadherence. Several candidate genes have been identified that could influence the amount of AIWG (antipsychotic-induced weight gain). The polymorphism rs17782313 near the MC4R (human melanocortin 4 receptor gene) was strongly associated with obesity in a large scale GWAS (genome wide association study), yet previous studies investigating its impact on AIWG did not lead to a definite conclusion regarding its effect. In particular, they were all relatively short and had a naturalistic design.

Objective

We therefore examined the influence of the rs17782313 polymorphism on SGA-related weight gain.

Methods

Participants of a multicenter randomi

SUBMITTER: Schreyer KF 

PROVIDER: S-EPMC10006246 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature