Association of the HTR2C-759C/T polymorphism and antipsychotic-induced weight gain: a meta-analysis.

ABSTRACT:

Background

Antipsychotic-induced weight gain (AIWG) is a crucial factor for the medication cessation of patients with schizophrenia. Multiple studies have shown that the functional polymorphism -759 C/T (rs3813929) in the HTR2C promoter region could possibly be correlated with AIWG.

Aim

To evaluate the genetic association of the HTR2C-759C/T polymorphism and AIWG in patients with schizophrenia with antipsychotic drugs (APDs) administration.

Methods

Eligible studies were identified by searching the following databases: PubMed, Embase, Web of Science, China Nation Knowledge Infrastructure (CNKI), VIP, Wanfang Data, Chinese Biomedical Literature Database (CBM) and the Airiti Library. The quality of studies was evaluated based on the Newcastle-Ottawa Scale. The poo

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7232784 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature