NT-proBNP and predictors of event free survival and left ventricular systolic function recovery in peripartum cardiomyopathy.

ABSTRACT:

Objective

To determine predictors of adverse outcomes in peripartum cardiomyopathy (PPCM).

Methods and results

We conducted a multi-center cohort study across four centers to identify subjects with PPCM with the following criteria: LVEF <40%, development of heart failure within the last month of pregnancy or within 5 months of delivery and no other identifiable cause of heart failure with reduced ejection fraction. Outcomes included 1) survival free from major adverse events (need for extra-corporeal membrane oxygenation, ventricular assist device, orthotopic heart transplantation or death) and 2) LVEF recovery ≥ 50%. Using a univariate logistic regression analysis, we identified significant clinical predictors of these outcomes, which were then used to create multivariable

SUBMITTER: Imran TF 

PROVIDER: S-EPMC10007968 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature