Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.

ABSTRACT: Genomic imprinting predominantly occurs in the placenta and brain. Few imprinted microRNAs have been identified in the brain, and their functional roles in the brain are not clear. Here we show paternal, but not maternal, expression of MIR125B2 in human but not mouse brain. Moreover, Mir125b-2^m-/p- mice showed impaired learning and memory, and anxiety, whose functions were hippocampus-dependent. Hippocampal granule cells from Mir125b-2^m-/p- mice displayed increased neuronal excitability, increased excitatory synaptic transmission, and decreased inhibitory synaptic transmission. Glutamate ionotropic receptor NMDA type subunit 2A (Grin2a), a key regulator of synaptic plasticity, was physically bound by mi

SUBMITTER: Chou MY 

PROVIDER: S-EPMC10014956 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature