Dataset Information

Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico.

ABSTRACT:

Background

We evaluated clinical and laboratory findings among patients with nonsevere or severe dengue in Puerto Rico to examine whether clinical manifestations vary by age.

Methods

During 2012-2014, we enrolled patients who arrived at the emergency department with fever or history of fever within 7 days of presentation. Serum samples were tested for dengue virus (DENV) by reverse transcriptase-polymerase chain reaction (RT-PCR) and IgM enzyme-linked immunosorbent assay (ELISA). Severe dengue was defined as severe plasma leakage or shock, severe bleeding, or organ involvement at presentation, during hospitalization, or follow-up.

Results

Of 1089 dengue patients identified, 281 (26%) were severe. Compared to those with nonsevere dengue, patients with severe dengue were more often aged 10-19 years (55% vs 40%, P < .001) and hospitalized (87% vs 30%, P < .001). Severe plasma leakage or shock was more common among children aged 0-9 (59%) or 10-19 years (86%) than adults (49%) (P < .01). Severe bleeding was less common among 10-19 year olds (24%) compared to 0-9 year olds (45%) and adults (52%; P < .01).

Conclusions

Severe plasma leakage was the most common presentation among children, highlighting important differences from adults. Vaccination against dengue could help prevent severe dengue among children in Puerto Rico.

SUBMITTER: Paz-Bailey G

PROVIDER: S-EPMC10015274 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico.

Paz-Bailey Gabriela G Sánchez-González Liliana L Torres-Velasquez Brenda B Jones Emma S ES Perez-Padilla Janice J Sharp Tyler M TM Lorenzi Olga O Delorey Mark M Munoz-Jordan Jorge L JL Tomashek Kay M KM Waterman Stephen H SH Alvarado Luisa I LI Rivera-Amill Vanessa V

The Journal of infectious diseases 20221101 11

<h4>Background</h4>We evaluated clinical and laboratory findings among patients with nonsevere or severe dengue in Puerto Rico to examine whether clinical manifestations vary by age.<h4>Methods</h4>During 2012-2014, we enrolled patients who arrived at the emergency department with fever or history of fever within 7 days of presentation. Serum samples were tested for dengue virus (DENV) by reverse transcriptase-polymerase chain reaction (RT-PCR) and IgM enzyme-linked immunosorbent assay (ELISA). ...[more]

PMID: 35510941

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Dataset Information

Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico.

Background

Methods

Results

Conclusions

Publications

Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico.

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