Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia.

ABSTRACT:

Objectives

Muscle soreness occurs after exercise and also in musculoskeletal diseases, such as fibromyalgia (FM). However, the nosography and pathoetiology of morbid soreness in FM remain unknown. This study aimed to investigate the morbid soreness of FM, evaluate its therapeutic responses and probe its pathophysiology with metabolomics profiling.

Methods

Patients with newly diagnosed FM were prospectively recruited and completed self-report questionnaires pertaining to musculoskeletal symptoms. The phenotypes and metabotypes were assessed with variance, classification and correlation analyses.

Results

Fifty-one patients and 41 healthy controls were included. Soreness symptoms were prevalent in FM individuals (92.2%). In terms of manifestations and metabolomic feature

SUBMITTER: Hung CH 

PROVIDER: S-EPMC10016302 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature