Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress.

ABSTRACT:

Background

There is growing recognition for a reciprocal, bidirectional link between anxiety disorders and obesity. Although the mechanisms linking obesity and anxiety remain speculative, this bidirectionality suggests shared pathophysiological processes. Neuroinflammation and oxidative damage are implicated in both pathological anxiety and obesity. This study investigates the relative contribution of comorbid diet-induced obesity and stress-induced anxiety to neuroinflammation and oxidative stress.

Methods

Thirty-six (36) male Lewis rats were divided into four groups based on diet type and stress exposure: 1) control diet unexposed (CDU) and 2) exposed (CDE), 3) Western-like high-saturated fat diet unexposed (WDU) and 4) exposed (WDE). Neurobehavioral tests were performed t

SUBMITTER: Santiago Santana JM 

PROVIDER: S-EPMC8713435 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature