Coenzyme Q₁₀ supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex.

ABSTRACT: Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme Q₁₀ (CoQ₁₀) as a water-soluble nanoformula by drinking water for 1 week. CoQ₁₀ supplementation concurrently improved brain mitochondrial respiration but not muscle strength. Notably, we identified an age-related decline in field excitatory postsynaptic potential (fEPSP) amplitude in the pathway from layers II/III to V of the primary motor area of middle-aged mice, which was restored to the young adult level by supplementing with CoQ₁₀ for 1 week

SUBMITTER: Inoue R 

PROVIDER: S-EPMC10017826 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature