CGM Metrics Identify Dysglycemic States in Participants From the TrialNet Pathway to Prevention Study.

ABSTRACT:

Objective

Continuous glucose monitoring (CGM) parameters may identify individuals at risk for progression to overt type 1 diabetes. We aimed to determine whether CGM metrics provide additional insights into progression to clinical stage 3 type 1 diabetes.

Research design and methods

One hundred five relatives of individuals in type 1 diabetes probands (median age 16.8 years; 89% non-Hispanic White; 43.8% female) from the TrialNet Pathway to Prevention study underwent 7-day CGM assessments and oral glucose tolerance tests (OGTTs) at 6-month intervals. The baseline data are reported here. Three groups were evaluated: individuals with 1) stage 2 type 1 diabetes (n = 42) with two or more diabetes-related autoantibodies and abnormal OGTT; 2) stage 1 type 1 diabetes (n = 53) with

SUBMITTER: Wilson DM 

PROVIDER: S-EPMC10020029 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature