Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC10020108 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Li Yun Y Wang Tao T Liao Qiumin Q Luo Xiaoting X Wang Xing X Zeng Shu S You Mengyue M Chen Yaxi Y Ruan Xiong Z XZ
Journal of lipid research 20230208 3
Lipid accumulation in hepatocytes is the distinctive characteristic of nonalcoholic fatty liver disease. Serine/arginine-rich splicing factor 3 (SRSF3) is highly expressed in the liver and expression decreases in high-fat conditions. However, the role of SRSF3 in hepatic lipid metabolism needs to be clarified. Here, we showed that loss of SRSF3 was associated with lipid accumulation. We determined that SRSF3 regulated lipophagy, the process of selective degradation of lipid droplets by autophagy ...[more]