CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
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ABSTRACT:
SUBMITTER: Rege SV
PROVIDER: S-EPMC10024715 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
Rege Sanket V SV Teichert Arnaud A Masumi Juliet J Dhande Onkar S OS Harish Reema R Higgins Brett W BW Lopez Yesenia Y Akrapongpisak Lily L Hackbart Hannah H Caryotakis Sofia S Leone Dino P DP Szoke Balazs B Hannestad Jonas J Nikolich Karoly K Braithwaite Steven P SP Minami S Sakura SS
Communications biology 20230318 1
Targeting immune-mediated, age-related, biology has the potential to be a transformative therapeutic strategy. However, the redundant nature of the multiple cytokines that change with aging requires identification of a master downstream regulator to successfully exert therapeutic efficacy. Here, we discovered CCR3 as a prime candidate, and inhibition of CCR3 has pro-cognitive benefits in mice, but these benefits are not driven by an obvious direct action on central nervous system (CNS)-resident ...[more]
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