TripletGO: Integrating Transcript Expression Profiles with Protein Homology Inferences for Gene Function Prediction.

ABSTRACT: Gene Ontology (GO) has been widely used to annotate functions of genes and gene products. Here, we proposed a new method, TripletGO, to deduce GO terms of protein-coding and non-coding genes, through the integration of four complementary pipelines built on transcript expression profile, genetic sequence alignment, protein sequence alignment, and naïve probability. TripletGO was tested on a large set of 5754 genes from 8 species (human, mouse, Arabidopsis, rat, fly, budding yeast, fission yeast, and nematoda) and 2433 proteins with available expression data from the third Critical Assessment of Protein Function Annotation challenge (CAFA3). Experimental results show that TripletGO achieves function annotation accuracy significantly beyond the current state-of-the-art approaches. Detailed an

SUBMITTER: Zhu YH 

PROVIDER: S-EPMC10025770 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature