Markers of intestinal immune activation and inflammation are not associated with preterm birth among women with low level HIV viremia.

ABSTRACT:

Background

Maternal markers of intestinal immune activation may be used to predict preterm birth (PTB) in pregnant women living with HIV.

Methods

This study used de-identified samples from the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) Protocol P1025 study. Singleton pregnancies with ≥3 ml plasma available and HIV viral load ≤400 copies/ml within 4 weeks of specimen collection were included. Frequency matching of PTB cases and term birth controls was performed on basis of maternal race, number of available plasma specimens, and timing of plasma sample collection in a 1:1 ratio. Plasma progesterone, 25-hydroxy vitamin D, soluble CD14, intestinal fatty acid binding protein (I-FABP), Lipopolysaccharide (LPS)-binding protein, and inflammator

SUBMITTER: Powell AM 

PROVIDER: S-EPMC10026076 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature