The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk.

ABSTRACT:

Background/aim

Mitogen-activated protein kinases (MAPKs) are important regulatory molecules, which have essential roles in physiology and pathology. In the present study, we examined the possible correlation between the MAPK7 gene and colorectal cancer risk in the Turkish population.

Materials and methods

A total of 100 human DNA samples (50 colorectal cancer patients and 50 healthy individuals) were sequenced using next-generation sequencing to define the potential genetic variations in the MAPK7 gene.

Results

Five genetic variations (MAPK7; rs2233072, rs2233076, rs181138364, rs34984998, rs148989290) were detected in our study group. The G (variant) allele of the MAPK7; rs2233072 (T>G) gene polymorphism was found in 76% of colorectal cancer cases, and 66% of controls

SUBMITTER: Cacina C 

PROVIDER: S-EPMC10026633 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature