Dataset Information

Cost-effectiveness analysis of vaccination against COVID-19 in China.

ABSTRACT:

Introduction

Since September 2020, Chinese populations aged > 3 years have been encouraged to receive a two-dose inoculation with vaccines against coronavirus disease 2019 (COVID-19). This study aims to evaluate the cost-effectiveness of the current vaccination strategy amongst the general population in mainland China from a societal perspective.

Methods

In this study, we construct a decision tree with Markov models to compare the economic and health consequences of the current vaccination strategy versus a no-vaccination scenario, over a time horizon of one year and an annual discount rate of 5%. Transition probabilities, health utilities, healthcare costs, and productivity losses are estimated from literature. Outcome measures include infection rates, death rates, quality-adjusted life years (QALYs), and costs. The incremental cost-effectiveness ratio (ICER) is then calculated to evaluate the cost-effectiveness of the current vaccination strategy, and both one-way deterministic sensitivity analysis and probabilistic sensitivity analysis (PSA) are applied to assess the impact of uncertainties on results.

Results

Our simulation indicates that compared with a no-vaccination scenario, vaccination amongst the general population in mainland China would reduce the infection rate from 100% to 45.3% and decrease the death rate from 6.8% to 3.1%. Consequently, the strategy will lead to a saving of 37,664.77 CNY (US$5,256.70) and a gain of 0.50 QALYs per person per year on average (lifetime QALY and productivity loss due to immature death are included). The cost-saving for each QALY gain is 74,895.69 CNY (US$10,452.85). Result of the PSA indicates that vaccination is the dominating strategy with a probability of 97.9%, and the strategy is cost-effective with a probability of 98.5% when the willingness-to-pay (WTP) is 72,000 CNY (US$10,048.71) per QALY.

Conclusion

Compared with a no-vaccination scenario, vaccination among the general population in mainland China is the dominating strategy from a societal perspective. The conclusion is considered robust in the sensitivity analyses.

SUBMITTER: Zhou H

PROVIDER: S-EPMC10027744 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Cost-effectiveness analysis of vaccination against COVID-19 in China.

Zhou Huixuan H Ding Ningxin N Han Xueyan X Zhang Hanyue H Liu Zeting Z Jia Xiao X Yu Jingjing J Zhang Wei W

Frontiers in public health 20230307

<h4>Introduction</h4>Since September 2020, Chinese populations aged > 3 years have been encouraged to receive a two-dose inoculation with vaccines against coronavirus disease 2019 (COVID-19). This study aims to evaluate the cost-effectiveness of the current vaccination strategy amongst the general population in mainland China from a societal perspective.<h4>Methods</h4>In this study, we construct a decision tree with Markov models to compare the economic and health consequences of the current va ...[more]

PMID: 36960359

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Dataset Information

Cost-effectiveness analysis of vaccination against COVID-19 in China.

Introduction

Methods

Results

Conclusion

Publications

Cost-effectiveness analysis of vaccination against COVID-19 in China.

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