Laminar Specificity of the Auditory Perceptual Awareness Negativity: A Biophysical Modeling Study.

ABSTRACT: How perception of sensory stimuli emerges from brain activity is a fundamental question of neuroscience. To date, two disparate lines of research have examined this question. On one hand, human neuroimaging studies have helped us understand the large-scale brain dynamics of perception. On the other hand, work in animal models (mice, typically) has led to fundamental insight into the micro-scale neural circuits underlying perception. However, translating such fundamental insight from animal models to humans has been challenging. Here, using biophysical modeling, we show that the auditory awareness negativity (AAN), an evoked response associated with perception of target sounds in noise, can be accounted for by synaptic input to the supragranular layers of auditory cortex (AC) that is presen

SUBMITTER: Pujol CF 

PROVIDER: S-EPMC10028885 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature