Dataset Information

Mendelian randomization study of diabetes and dementia in the Million Veteran Program.

ABSTRACT:

Introduction

Diabetes and dementia are diseases of high healthcare burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective was to evaluate evidence of causality between these two common diseases.

Methods

We conducted a one-sample Mendelian randomization (MR) analysis in the U.S. Department of Veterans Affairs Million Veteran program. The study included 334,672 participants ≥65 years of age with type 2 diabetes and dementia case-control status and genotype data.

Results

For each standard deviation increase in genetically-predicted diabetes, we found increased odds of three dementia diagnoses in non-Hispanic White participants (all-cause: OR=1.07[1.05-1.08], P =3.40E-18; vascular: OR=1.11[1.07-1.15], P =3.63E-09, Alzheimer's: OR=1.06[1.02-1.09], P =6.84E-04) and non-Hispanic Black participants (all-cause: OR=1.06[1.02-1.10], P =3.66E-03, vascular: OR=1.11[1.04-1.19], P =2.20E-03, Alzheimer's: OR=1.12 [1.02-1.23], P =1.60E-02) but not in Hispanic participants (all P >.05).

Discussion

We found evidence of causality between diabetes and dementia using a one-sample MR study, with access to individual level data, overcoming limitations of prior studies utilizing two-sample MR techniques.

SUBMITTER: Litkowski EM

PROVIDER: S-EPMC10029030 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Mendelian randomization study of diabetes and dementia in the Million Veteran Program.

Litkowski Elizabeth M EM Logue Mark W MW Zhang Rui R Charest Brian R BR Lange Ethan M EM Hokanson John E JE Lynch Julie A JA Vujkovic Marijana M Phillips Lawrence S LS Hauger Richard L RL Lange Leslie A LA Raghavan Sridharan S

medRxiv : the preprint server for health sciences 20230309

<h4>Introduction</h4>Diabetes and dementia are diseases of high healthcare burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective was to evaluate evidence of causality between these two common diseases.<h4>Methods</h4>We conducted a one-sample Mendelian randomization (MR) analysis in the U.S. Department of Veterans Affairs Million Veteran program. The study included 334,672 participants ≥65 years of age with type 2 diabetes and dementia case-cont ...[more]

PMID: 36945581

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Dataset Information

Mendelian randomization study of diabetes and dementia in the Million Veteran Program.

Introduction

Methods

Results

Discussion

Publications

Mendelian randomization study of diabetes and dementia in the Million Veteran Program.

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