Early Childhood Development of Node Centrality in the White Matter Connectome and Its Relationship to IQ at Age 6 Years.

ABSTRACT:

Background

The white matter (WM) connectome is important for cognitive development and intelligence and is altered in neuropsychiatric illnesses. Little is known about how the WM connectome develops or its relationship to IQ in early childhood.

Methods

The development of node centrality in the WM connectome was studied in a longitudinal cohort of 226 (123 female) children from the University of North Carolina Early Brain Development Study. Structural and diffusion-weighted images were acquired after birth and at 1, 2, 4, and 6 years, and IQ was assessed at 6 years. Eigenvector centrality, betweenness centrality, and the global graph metrics of global efficiency, small worldness, and modularity were determined at each age.

Results

The greatest developmental change in e

SUBMITTER: Bagonis M 

PROVIDER: S-EPMC10033460 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature