The impact of white matter hyperintensities on the structural connectome in late-life depression: Relationship to executive functions.

ABSTRACT:

Background

White matter hyperintensities (WMH) represent ischemic white matter damage in late-life depression (LLD) and are associated with cognitive control dysfunction. Understanding the impact of WMH on the structural connectivity of gray matter and the cognitive control correlates of WMH-related structural dysconnectivity can provide insight into the pathophysiology of LLD.

Methods

We compared WMH burden and performance on clinical measures of cognitive control in patients with LLD (N = 44) and a control group of non-depressed older adults (N = 59). We used the Network Modification (NeMo) Tool to investigate the impact of WMH on structural dysconnectivity in specific gray matter regions, and how such connectivity was related to cognitive control functions.

Results

SUBMITTER: Respino M 

PROVIDER: S-EPMC6514361 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature