Cost-effectiveness of pancreas surveillance: The CDKN2A-p16-Leiden cohort.

ABSTRACT:

Background

CDKN2A-p16-Leiden mutation carriers have a high lifetime risk of developing pancreatic ductal adenocarcinoma (PDAC), with very poor survival. Surveillance may improve prognosis.

Objective

To assess the cost-effectiveness of surveillance, as compared to no surveillance.

Methods

In 2000, a surveillance program was initiated at Leiden University Medical Center with annual MRI and optional endoscopic ultrasound. Data were collected on the resection rate of screen-detected tumors and on survival. The Kaplan-Meier method and a parametric cure model were used to analyze and compare survival. Based on the surveillance and survival data from the screening program, a state-transition model was constructed to estimate lifelong outcomes.

Results

A total of 347 m

SUBMITTER: Ibrahim IS 

PROVIDER: S-EPMC10039795 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature