Design of a multi-epitopic vaccine against Epstein-Barr virus via computer-based methods.

ABSTRACT:

Background

Scientific findings have shown that Epstein-Barr virus (EBV) plays a key role in the development of some tumor diseases. Therefore, this study intends to take a practical step in controlling the pathogenicity of this virus by designing an effective vaccine based on the virus Capsid Envelope and Epstein-Barr nuclear immunogen (EBNA) Proteins Epitopes. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. So, we applied a computer-based strategy to design an epitope vaccine.

Results

We designed a powerful multi-epitope peptide vaccine against EBV using in silico analysis. The vaccine is made up of 844 amino acids derived from three different types of proteins (Envelope, Capsid, EBNA) found in two different viral strains. responses. T

SUBMITTER: Larijani A 

PROVIDER: S-EPMC10043181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature