Geographic Structuring and Divergence Time Frame of Monkeypox Virus in the Endemic Region.

ABSTRACT:

Background

Monkeypox is an emerging zoonosis endemic to Central and West Africa. Monkeypox virus (MPXV) is genetically structured in 2 major clades (clades 1 and 2/3), but its evolution is poorly explored.

Methods

We retrieved MPXV genomes from public repositories and we analyzed geographic patterns using STRUCTURE. Molecular dating was performed using a using a Bayesian approach.

Results

We show that the population transmitted in West Africa (clades 2/3) experienced limited drift. Conversely, clade 1 (transmitted in the Congo Basin) possibly underwent a bottleneck or founder effect. Depending on the model used, we estimated that the 2 clades separated ∼560-860 (highest posterior density: 450-960) years ago, a period characterized by expansions and contractions of rai

SUBMITTER: Forni D 

PROVIDER: S-EPMC10044091 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature