Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response.

ABSTRACT: Perturbed host metabolism is increasingly recognized as a pillar of sepsis pathogenesis, yet the dynamic alterations in metabolism and its relationship to other components of the host response remain incompletely understood. We sought to identify the early host-metabolic response in patients with septic shock and to explore biophysiological phenotyping and differences in clinical outcomes among metabolic subgroups.

Design

We measured serum metabolites and proteins reflective of the host-immune and endothelial response in patients with septic shock.

Setting

We considered patients from the placebo arm of a completed phase II, randomized controlled trial conducted at 16 U.S. medical centers. Serum was collected at baseline (within 24 hr of the identification of septic shock), 24

SUBMITTER: Jennaro TS 

PROVIDER: S-EPMC10047616 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature