Whole-Genome Sequencing Data Reveal New Loci Affecting Milk Production in German Black Pied Cattle (DSN).

ABSTRACT: German Black Pied (DSN) is considered an ancestral population of the Holstein breed. The goal of the current study was to fine-map genomic loci for milk production traits and to provide sequence variants for selection. We studied genome-wide associations for milk-production traits in 2160 DSN cows. Using 11.7 million variants from whole-genome sequencing of 304 representative DSN cattle, we identified 1980 associated variants (-log₁₀(p) ≥ 7.1) in 13 genomic loci on 9 chromosomes. The highest significance was found for the MGST1 region affecting milk fat content (-log₁₀(p) = 11.93, MAF = 0.23, substitution effect of the minor allele (ß_MA) = -0.151%). Different from Holstein, DGAT1 was fixed (0.97) for the alanine protein variant f

SUBMITTER: Korkuc P 

PROVIDER: S-EPMC10048491 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature