Dataset Information

Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer.

ABSTRACT:

Background

Mitophagy plays essential role in the development and progression of colorectal cancer (CRC). However, the effect of mitophagy-related genes in CRC remains largely unknown.

Aim

To develop a mitophagy-related gene signature to predict the survival, immune infiltration and chemotherapy response of CRC patients.

Methods

Non-negative matrix factorization was used to cluster CRC patients from Gene Expression Omnibus database (GSE39582, GSE17536, and GSE37892) based on mitophagy-related gene expression. The CIBERSORT method was applied for the evaluation of the relative infiltration levels of immune cell types. The performance signature in predicting chemotherapeutic sensitivity was generated using data from the Genomics of Drug Sensitivity in Cancer database.

Results

Three clusters with different clinicopathological features and prognosis were identified. Higher enrichment of activated B cells and CD4⁺ T cells were observed in cluster III patients with the most favorable prognosis. Next, a risk model based on mitophagy-related genes was developed. Patients in training and validation sets were categorized into low-risk and high-risk subgroups. Low risk patients showed significantly better prognosis, higher enrichment of immune activating cells and greater response to chemotherapy (oxaliplatin, irinotecan, and 5-fluorouracil) compared to high-risk patients. Further experiments identified CXCL3 as novel regulator of cell proliferation and mitophagy.

Conclusion

We revealed the biological roles of mitophagy-related genes in the immune infiltration, and its ability to predict patients' prognosis and response to chemotherapy in CRC. These interesting findings would provide new insight into the therapeutic management of CRC patients.

SUBMITTER: Weng JS

PROVIDER: S-EPMC10052665 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer.

Weng Jin-Sen JS Huang Jie-Ping JP Yu Wei W Xiao Jun J Lin Fang F Lin Kang-Ni KN Zang Wei-Dong WD Ye Yong Y Lin Jing-Ping JP

World journal of gastrointestinal oncology 20230301 3

<h4>Background</h4>Mitophagy plays essential role in the development and progression of colorectal cancer (CRC). However, the effect of mitophagy-related genes in CRC remains largely unknown.<h4>Aim</h4>To develop a mitophagy-related gene signature to predict the survival, immune infiltration and chemotherapy response of CRC patients.<h4>Methods</h4>Non-negative matrix factorization was used to cluster CRC patients from Gene Expression Omnibus database (GSE39582, GSE17536, and GSE37892) based on ...[more]

PMID: 37009318

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Dataset Information

Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer.

Background

Aim

Methods

Results

Conclusion

Publications

Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer.

Similar Datasets

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