Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain.

ABSTRACT: Acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in the brain remain largely obscure. Here, we used a brief water avoidance stress (WAS) to elicit an acute stress response in mice. By employing RNA-sequencing and metabolomics profiling, we investigated the acute stress-induced molecular changes in the mouse whole brain. The aberrant expression of 60 genes was detected in the brain tissues of WAS-exposed mice. Functional analyses showed that the aberrantly expressed genes were enriched in various processes such as superoxide metabolism. In our global metabolomic profiling, a total of 43 brain metabolites were significantly altered by acute WAS. Metabolic pathways upregulated from W

SUBMITTER: Lee H 

PROVIDER: S-EPMC10052811 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature