Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content.

ABSTRACT: Cardiovascular complications are accompanied by life-threatening complications and represent the major cause of death in patients with chronic kidney disease (CKD). Magnesium is important for the physiology of cardiac function, and its deficiency is common in CKD. In the present study, we investigated the impact of oral magnesium carbonate supplementation on cardiac function in an experimental model of CKD induced in Wistar rats by an adenine diet. Echocardiographic analyses revealed restoration of impaired left ventricular cardiac function in animals with CKD. Cardiac histology and real-time PCR confirmed a high amount of elastin protein and increased collagen III expression in CKD rats supplemented with dietary magnesium as compared with CKD controls. Both structural proteins are crucial

SUBMITTER: Barros X 

PROVIDER: S-EPMC10056411 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature