MicroRNA-142-3p improves vascular relaxation in uremia.

ABSTRACT:

Background and aims

Chronic kidney disease (CKD) is strongly associated with a high burden of cardiovascular morbidity and mortality. Therefore, we aimed to characterize the putative role of microRNAs (miR)s in uremic vascular remodelling and endothelial dysfunction.

Methods

We investigated the expression pattern of miRs in two independent end-stage renal disease (ESRD) cohorts and in the animal model of uremic DBA/2 mice via quantitative RT-PCR. Moreover, DBA/2 mice were treated with intravenous injections of synthetic miR-142-3p mimic and were analysed for functional and morphological vascular changes by mass spectrometry and wire myography.

Results

The expression pattern of miRs was regulated in ESRD patients and was reversible after kidney transplantation. Out of

SUBMITTER: Ketszeri M 

PROVIDER: S-EPMC6591123 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature