Non-coding RNA regulation of integrins and their potential as therapeutic targets in cancer.

ABSTRACT:

Background

Integrins are integral to cell signalling and management of the extracellular matrix, and exquisite regulation of their expression is essential for a variety of cell signalling pathways, whilst disordered regulation is a key driver of tumour progression and metastasis. Most recently non-coding RNAs in the form of micro-RNA (miRNA) and long non-coding RNA (lncRNA) have emerged as a key mechanism by which tissue dependent gene expression is controlled. Whilst historically these molecules have been poorly understood, advances in 'omic' technologies and a greater understanding of non-coding regions of the genome have revealed that non-coding RNAs make up a large proportion of the transcriptome.

Conclusions and perspectives

This review examines the regulation of integr

SUBMITTER: Verhoeff TJ 

PROVIDER: S-EPMC10060301 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature